Associations of serum bile acids and amino acids with low skeletal muscle mass among Chinese population: a cross-sectional study
This study identified specific BAs and AAs significantly correlated with preserved SMM, suggesting that modulating BA metabolism (particularly elevating GLCA) and maintaining optimal BCAA levels may be effective strategies for low SMM. GLCA's direct protective effect supports exploring dietary or microbiota-targeted interventions. Individual metabolic profiles, such as BMI, should be incorporated into personalized sarcopenia management.
Authors
- Mingyu Zhu (ORCID: https://orcid.org/0000-0002-2810-7286)
- Rong Huang (ORCID: https://orcid.org/0000-0003-4566-097X)
- Hongxia Liu (ORCID: https://orcid.org/0000-0002-3099-8911)
- Ning Chen (ORCID: https://orcid.org/0000-0001-6806-4287)
- Ting Zhang (ORCID: https://orcid.org/0000-0002-5748-9754)
- Yurong Weng
- Ting Liu (ORCID: https://orcid.org/0000-0003-0669-996X)
- Tingting Han (ORCID: https://orcid.org/0000-0001-7029-2270)
- Yaomin Hu
Institutions
- Renji Hospital (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1186/s12891-025-09353-w
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00