Lactate-driven lactylation of HNRNPA1 orchestrates PKM2 splicing and glycolytic reprogramming in bladder cancer
This study reveals a lactate-driven mechanism coupling alternative splicing to metabolic reprogramming via HNRNPA1 lactylation, identifying HNRNPA1-K350 lactylation as a key driver of glycolysis-dependent tumor progression. A therapeutic approach targeting HNRNPA1 in BLCA is proposed.
Authors
- Jian Ma (ORCID: https://orcid.org/0000-0003-2669-2693)
- Guixin Ding (ORCID: https://orcid.org/0009-0009-7215-3261)
- Yicheng Guo (ORCID: https://orcid.org/0000-0001-5357-660X)
- Fengze Sun (ORCID: https://orcid.org/0000-0002-8035-2131)
- Yanfei Li (ORCID: https://orcid.org/0000-0003-1539-2126)
- Tianqi Wang (ORCID: https://orcid.org/0000-0003-0508-9481)
- Hongquan Liu (ORCID: https://orcid.org/0000-0001-5192-6768)
- Jie Gao (ORCID: https://orcid.org/0000-0001-6035-4407)
- Yini Wang (ORCID: https://orcid.org/0000-0002-1154-6733)
- Xiaohong Ma (ORCID: https://orcid.org/0000-0001-8625-237X)
- Jitao Wu
- Hejia Yuan
Institutions
- Qingdao University (CN)
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Yuhuangding Hospital (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1186/s13046-025-03591-5
- Citations
- 5
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 4.03