The Role of Adaptive and Innovative Trial Designs in Diabetes Research: A Scoping Review
Adaptive and master protocol trials remain rare in diabetes. Overcoming barriers through targeted training and awareness, robust regulatory frameworks, and strategic incentives could support broader adoption.
Authors
- Elizabeth Holmes‐Truscott (ORCID: https://orcid.org/0000-0001-9139-4663)
- Elif Ilhan Ekinci (ORCID: https://orcid.org/0000-0003-2372-395X)
- Leonid P. Churilov (ORCID: https://orcid.org/0000-0002-9807-6606)
- Michele Gaca
- Negar Naderpoor (ORCID: https://orcid.org/0000-0002-1738-3189)
- Rury R. Holman (ORCID: https://orcid.org/0000-0002-1256-874X)
- David Norman O'Neal (ORCID: https://orcid.org/0000-0002-0870-4032)
- Andrew A. Farmer (ORCID: https://orcid.org/0000-0002-6170-4402)
- Christine Somerville
- Kamlesh K. Khunti (ORCID: https://orcid.org/0000-0003-2343-7099)
- Rose Lin
- Ashni Goshrani (ORCID: https://orcid.org/0009-0008-4699-2531)
Institutions
- The Royal Melbourne Hospital (AU)
- Australian Research Council (AU)
- Deakin University (AU)
- University of Leicester (GB)
- The University of Melbourne (AU)
- Diabetes Australia (AU)
- University of Oxford (GB)
- St Vincent's Hospital Melbourne (AU)
- Eastern Health (AU)
- Monash Health (AU)
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
- Austin Health (AU)
- NIHR Leicester Biomedical Research Centre (GB)
- Monash University (AU)
Publication Details
- Journal
- Diabetes Care
- Published
- 2025-11-20
- DOI
- https://doi.org/10.2337/dc25-1508
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Sanofi
- Nestlé Health Science
- Diabetes Canada
- National Institute for Health and Care Research
- British Heart Foundation
- Diabetes Australia
- Deakin University
- Daiichi-Sankyo
- Novo Nordisk
- Servier
- Diabetes Victoria
- MTPConnect
- Medical Research Council
- National Health and Medical Research Council
- NIHR Leicester Biomedical Research Centre