Stability assessment of preservative-free losartan potassium eye drops compounded for ophthalmic use

LP eye drops prepared with BSS or NS were stable in closed sterile eye drop bottles for at least 30 days under all tested conditions. Frozen and refrigerated conditions are preferred for storage. Because the formulation does not contain preservatives, its use is recommended for no longer than 7 days after opening. GS-based formulations are not recommended for ophthalmic use. The conducted stability study provides hospital pharmacies with data supporting the safe preparation, storage and use of non-commercial ophthalmic formulations.