Assessment of leukocyte telomere length as a cellular aging marker through a quantitative PCR-based technique in individuals with a chronic addiction to the psychoactive drug delta-9-tetrahydrocannabinol. (Case control study).
These findings demonstrate that cannabis addiction is associated with shortened LTL, suggesting accelerated biological ageing. The absence of an age-LTL correlation within groups may indicate that cannabis use exerts an overriding effect independent of chronological age. LTL could serve as a potential biomarker for cellular ageing in substance use disorders.
Authors
- Mohamed Gamil Mehanna (ORCID: https://orcid.org/0009-0002-4642-2244)
- Ekremah Ali Al-Zarea
- M Abdelmonem (ORCID: https://orcid.org/0000-0002-9753-8207)
- Nessma Hessin Mohamed Gandor (ORCID: https://orcid.org/0000-0003-2333-7653)
- Ahmed R. Rezk (ORCID: https://orcid.org/0000-0002-6591-9734)
- Ahmed Ali Ali Assem
- Mohammad AbdElhameed Alwaseef
- Ahmed S. Gouda (ORCID: https://orcid.org/0000-0003-2470-0792)
- Ashraf Elsherbiny
- Kareeman Gomaa
- Saad S. M. Hassan (ORCID: https://orcid.org/0000-0001-6663-4565)
- Mohamed Abdel Wahab (ORCID: https://orcid.org/0000-0003-0004-6036)
- D Ibrahim (ORCID: https://orcid.org/0000-0002-8108-6680)
- Adel F. Hashish (ORCID: https://orcid.org/0000-0001-9549-2973)
- Ammal M. Metwally (ORCID: https://orcid.org/0000-0003-0575-5202)
- Abdelsattar M. Omar (ORCID: https://orcid.org/0000-0002-9825-3465)
- Ahmed Akef
- Hesham Hegazy
- M. M. Abou Zeid
- H Ahmed
- A Saadeldain
- R Sajanlal
Institutions
- Ain Shams University (EG)
- Cairo University (EG)
- Al-Azhar University (EG)
- Jouf University (SA)
- Buraydah Colleges (SA)
- National Research Centre (EG)
Publication Details
- Journal
- PubMed
- Published
- 2025-11-21
- DOI
- https://doi.org/10.7417/ct.2025.5299
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00