Immune Checkpoint Inhibitors for Mismatch Repair–Deficient Gastroesophageal Adenocarcinoma: Outcomes and Feasibility of Nonoperative Management at Mayo Clinic
In this retrospective cohort study, nICIs led to high cCR and pCR rates in resectable dMMR/MSI-H GEA, supporting the use of immune checkpoint inhibitors in this setting and the feasibility of NOM in select patients.
Authors
- Robert R. McWilliams (ORCID: https://orcid.org/0000-0002-8199-5040)
- Mitesh J. Borad (ORCID: https://orcid.org/0000-0003-2700-2658)
- Nabil Wasif (ORCID: https://orcid.org/0000-0001-7979-6766)
- Christina Wu (ORCID: https://orcid.org/0000-0001-5922-5392)
- Travis E. Grotz (ORCID: https://orcid.org/0000-0002-7753-097X)
- Priya K. Pai (ORCID: https://orcid.org/0000-0001-8634-9307)
- Hao Xie (ORCID: https://orcid.org/0000-0002-9640-4055)
- Nguyen H. Tran (ORCID: https://orcid.org/0000-0002-6104-6489)
- Jason S. Starr (ORCID: https://orcid.org/0000-0003-4922-1392)
- Mojun Zhu (ORCID: https://orcid.org/0000-0003-0146-9452)
- Harry H. Yoon (ORCID: https://orcid.org/0000-0001-6208-3487)
- Cody R. Eslinger (ORCID: https://orcid.org/0000-0002-8057-0841)
- Rish K. Pai (ORCID: https://orcid.org/0000-0002-2692-221X)
- Mohamad Bassam Sonbol (ORCID: https://orcid.org/0000-0002-6931-242X)
- Daniel H. Ahn (ORCID: https://orcid.org/0000-0002-0161-4018)
- Shaylene McCue (ORCID: https://orcid.org/0009-0004-2245-3323)
- Fang‐Shu Ou (ORCID: https://orcid.org/0000-0003-1267-8735)
- Tanios Bekaii‐Saab (ORCID: https://orcid.org/0000-0001-7721-1699)
- Fares Jamal (ORCID: https://orcid.org/0009-0007-6286-3855)
- Oudai Sahwan (ORCID: https://orcid.org/0000-0001-9837-0891)
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1200/po-25-00492
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05