Human herpesvirus 6 (HHV-6) infection and risk of Alzheimer’s disease: a systematic review and meta-analysis
This meta-analysis suggests that HHV-6 infection is significantly associated with an increased risk of Alzheimer's disease. Nevertheless, the exact causal mechanisms remain unclear. Further longitudinal and mechanistic studies are needed to better understand the role of HHV-6 in Alzheimer's pathogenesis and to evaluate potential antiviral options for preventive or therapeutic strategies.
Authors
- Fakhrosadat Mirhosseini (ORCID: https://orcid.org/0000-0001-6100-6463)
- Maryam Rashidian (ORCID: https://orcid.org/0000-0001-6417-3160)
- Sayed‐Hamidreza Mozhgani
- Fatemeh Bastan
- Fateme Saeedi-Moghaddam
Institutions
- Jahrom University of Medical Sciences (IR)
- Alborz University of Medical Sciences (IR)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1186/s12883-025-04500-1
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00