Genetic atlas of plasma metabolome across 40 human common diseases: mapping causal metabolites to disease risk
This study provides a comprehensive resource that delineates the genetic architecture of metabolites across diverse disease contexts, offering new insights into disease etiology and advancing precision medicine through enhanced risk prediction and therapeutic target discovery.
Authors
- Xiangpan Li
- Jianbo Tian (ORCID: https://orcid.org/0000-0001-9493-694X)
- Yongchang Wei (ORCID: https://orcid.org/0000-0001-7205-4663)
- Yimin Cai (ORCID: https://orcid.org/0000-0002-2458-1976)
- Zequn Lu (ORCID: https://orcid.org/0000-0003-3165-9097)
- Ying Zhu (ORCID: https://orcid.org/0009-0005-0065-2505)
- Xiaoping Miao (ORCID: https://orcid.org/0000-0001-6732-8367)
- Chaoqun Huang (ORCID: https://orcid.org/0000-0001-9799-4571)
- Bin Li (ORCID: https://orcid.org/0000-0001-8516-9953)
- Bo Liu (ORCID: https://orcid.org/0000-0002-3603-6617)
- Yanmin Li (ORCID: https://orcid.org/0000-0003-1174-3873)
- Can Chen (ORCID: https://orcid.org/0000-0003-2310-0074)
- Qianying Ma (ORCID: https://orcid.org/0000-0002-2305-1869)
- Caibo Ning
- Xiaojun Yang (ORCID: https://orcid.org/0000-0001-9833-6415)
- Jin Meng (ORCID: https://orcid.org/0000-0003-2611-5407)
- Ying Xu (ORCID: https://orcid.org/0000-0003-1452-8423)
- Xu Zhu (ORCID: https://orcid.org/0009-0003-8862-0887)
- Chunyi He (ORCID: https://orcid.org/0009-0002-0642-4448)
- Ming Zhang (ORCID: https://orcid.org/0000-0002-1800-9041)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1186/s13073-025-01578-7
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81