Plasma lipid metabolites as biomarkers of early white matter degeneration in Alzheimer's disease
Circulating lipid metabolites link to white matter integrity in early Alzheimer's disease (AD)Phosphatidylcholines (PCs), lysophosphatidylcholines (LPCs), and propionylcarnitine associate with tract-specific diffusion magnetic resonance imaging (dMRI) metricsNo metabolite-white matter associations detected in established ADPlasma metabolites may serve as biomarkers of early white matter degeneration.
Authors
- Reza Rostami (ORCID: https://orcid.org/0000-0001-9318-108X)
- Amirreza Haghighi (ORCID: https://orcid.org/0009-0006-9474-9208)
- Nezamaddin Ghasemi (ORCID: https://orcid.org/0000-0003-3707-7864)
- Arman Ghayourvahdat (ORCID: https://orcid.org/0000-0003-0188-8438)
- Sirous Zeinali (ORCID: https://orcid.org/0000-0002-9516-9954)
- Mohammad D. Mansouri
- Hamide Nasiri (ORCID: https://orcid.org/0009-0002-2853-2298)
- Mohammad Amir Amirian
- Hamed Gozali
- Maryam Ayobi
- Hannaneh Azimizonuzi
- Arya Moftakhar Bazkiaei
Institutions
- Isfahan University of Medical Sciences (IR)
- University of Rome Tor Vergata (IT)
- Zanjan University of Medical Sciences (IR)
- Tabriz University of Medical Sciences (IR)
- Shiraz University of Medical Sciences (IR)
- Kashan University of Medical Sciences (IR)
- University of Tehran (IR)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Iranian Orthopedic Association (IR)
- Gonbad Kavous University (IR)
- Fasa University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Islamic Azad University of Najafabad (IR)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/dad2.70217
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Foundation for the National Institutes of Health
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research