Cross‐cohort validation and cutpoint estimation of the Janssen plasma p‐tau217+ assay in predominantly cognitively normal community studies
Plasma phosphorylated tau (p-tau) 217 assays have demonstrated potential to identify older adults with brain amyloid pathology due to Alzheimer's disease. Community-based studies are crucial for accessing the clinical validity of fluid biomarkers and their real-world applicability. We evaluated the Janssen plasma p-tau217+ assay in three community-based cohorts. Janssen plasma p-tau217+ identified amyloid-beta abnormalities across three diverse cohorts of community-dwelling older adults. High NPV indicates p-tau217+ as a good tool for initial screening to enrich for high-risk individuals particularly for cohort studies and clinical trial participation.
Authors
- Mary Ganguli
- Xuemei Zeng (ORCID: https://orcid.org/0000-0003-4885-4788)
- Ann D. Cohen (ORCID: https://orcid.org/0000-0001-7395-9624)
- Steven E. Reís (ORCID: https://orcid.org/0000-0001-8023-0102)
- Anum Saeed (ORCID: https://orcid.org/0000-0003-1783-678X)
- Beth E. Snitz (ORCID: https://orcid.org/0000-0002-9978-1374)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Victor L. Villemagne (ORCID: https://orcid.org/0000-0002-5832-9875)
- Alexandra Gogola (ORCID: https://orcid.org/0000-0002-8798-1715)
- Gallen Triana‐Baltzer (ORCID: https://orcid.org/0000-0003-0612-1236)
- Brian J. Lopresti
- Hartmuth C. Kolb (ORCID: https://orcid.org/0000-0003-2414-5792)
- Wasiu Gbolahan Balogun (ORCID: https://orcid.org/0000-0002-1422-8562)
- Oscar L. Lopez
- Happiness E. Aigbogun
Institutions
- Johnson & Johnson (United States) (US)
- University of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70916
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- University of Pittsburgh
- National Institutes of Health
- National Institute on Aging
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke