Exploring sex‐specific risk factors in cognitive decline: Insights into modifiable and non‐modifiable determinants using a network analysis
Sex-stratified networks of risk factors differ in healthy and cognitively impaired adults. Female networks show greater global connectivity in healthy versus cognitively decline groups. Apolipoprotein E, family history, and lifestyle factors show sex-specific centrality in networks. Network structure changes more in females across the cognitive decline spectrum. Findings support sex-specific modeling of dementia risk for precision prevention.
Authors
- Brittany Intzandt (ORCID: https://orcid.org/0000-0001-8475-988X)
- Sandra E. Black (ORCID: https://orcid.org/0000-0001-7093-8289)
- Joel Ramirez (ORCID: https://orcid.org/0000-0002-5582-1776)
- Gillian Einstein (ORCID: https://orcid.org/0000-0002-0770-5471)
- Mario Masellis (ORCID: https://orcid.org/0000-0002-6244-2096)
- Benjamin Lam (ORCID: https://orcid.org/0000-0001-8010-4915)
- Louis Bherer
Institutions
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- York University (CA)
- Scarborough Health Network (CA)
- Montreal Heart Institute (CA)
- Baycrest Hospital (CA)
- Ontario Brain Institute (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70825
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- McGill University
- Fondation Brain Canada
- Fondation Jean-Louis Lévesque
- Consortium canadien en neurodégénérescence associée au vieillissement
- Alzheimer Society
- Alzheimer Society Research Program
- Pfizer Canada
- Canadian Institutes of Health Research