Putaminal hypermetabolism identifies Lewy body co‐pathology in Alzheimer's disease
LB co-pathology in AD alters regional brain metabolism. SRP analyses capture putaminal hypermetabolism for SAA positivity. SUVR analyses emphasize occipital hypometabolism for SAA positivity. Occipital metabolism correlates positively with AD severity in mixed AD-LB. Putaminal, not occipital, metabolism predicts cognitive change over AD-related metabolism and SAA.
Authors
- Seun Jeon (ORCID: https://orcid.org/0000-0003-2817-3352)
- Min-Sun Choi
- Sung Woo Kang (ORCID: https://orcid.org/0000-0001-9791-6899)
- Yeo Ju Kim (ORCID: https://orcid.org/0000-0002-1783-8876)
- Byoung Seok Ye (ORCID: https://orcid.org/0000-0003-0187-8440)
- Young‐gun Lee (ORCID: https://orcid.org/0000-0003-0460-455X)
Institutions
- Yonsei University (KR)
- Inje University Ilsan Paik Hospital (KR)
- Hanyang University Seoul Hospital (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70920
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Biogen
- BioClinica
- Eisai
- National Institutes of Health
- Genentech