CXCR3 expression on antigen-experienced B cells is systemically dysregulated in type 1 diabetes
We conclude that the CXCR3 response in antigen-experienced B cells is dysregulated during the progression of type 1 diabetes. CXCR3 expression is limited in CD20<sup>+</sup> B cells in pancreases from recent-onset individuals diagnosed with type 1 diabetes under 7 years of age, but evident on CD8<sup>+</sup> T cells that express CD20.
Authors
- F. Susan Wong
- Joanne Boldison (ORCID: https://orcid.org/0000-0002-9146-5692)
- Pia Leete (ORCID: https://orcid.org/0000-0002-4013-0040)
- Joanne Davies (ORCID: https://orcid.org/0000-0002-3742-761X)
- Stephanie Hanna (ORCID: https://orcid.org/0000-0002-0821-4498)
- Noel G. Morgan (ORCID: https://orcid.org/0000-0003-1537-8113)
- Sophie Walker (ORCID: https://orcid.org/0000-0002-9613-4534)
- Wendy Powell
- Conor McMullan (ORCID: https://orcid.org/0000-0002-3329-1559)
- Emma Robinson
Institutions
- University of Exeter (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1007/s00125-025-06608-y
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Leona M. and Harry B. Helmsley Charitable Trust
- National Institute for Health and Care Research
- Diabetes Research and Wellness Foundation
- Department of Health and Social Care
- Diabetes UK
- Cardiff University
- Research England