The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression
This study identifies CLIC1 as a novel metabolic regulator that drives glycolytic reprogramming through direct interaction with PKM2 in gastric cancer. Targeting the CLIC1-PKM2 axis may provide a promising therapeutic strategy for metabolic intervention in GC and highlights a potential translational target for future clinical application.
Authors
- Junqiang Chen (ORCID: https://orcid.org/0000-0002-2615-3537)
- Wei Xu (ORCID: https://orcid.org/0000-0003-3808-0045)
- Yuantian Mao
- Yu Zhu (ORCID: https://orcid.org/0000-0003-1535-6520)
- Jian Yang (ORCID: https://orcid.org/0000-0002-5573-2650)
- Yue Feng (ORCID: https://orcid.org/0009-0006-5668-3025)
- Changhua Li
- Shengyu Wang (ORCID: https://orcid.org/0000-0002-9774-8319)
Institutions
- Guangxi Medical University (CN)
- Guangxi Zhuang Autonomous Region Department of Education (CN)
- Guangxi Zhuang Autonomous Region Health and Family Planning (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1186/s12967-025-07463-6
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94