The differential effects of cAMP mobilizing agents on TGF-β-induced extracellular matrix in human lung-derived fibroblasts: insights into therapeutic targets for lung fibrosis
The anti-fibrotic properties of treprostinil are primarily mediated by the IP receptor, acting through both G<sub>αs</sub>-dependent and -independent pathways. Understanding the differential effects of cAMP-mobilizing pathways on HLF fibrotic signatures can provide insight into developing novel targets to manage IPF.
Authors
- B.T. Deeney (ORCID: https://orcid.org/0000-0002-1472-2245)
- Gaoyuan Cao (ORCID: https://orcid.org/0000-0001-8308-7401)
- S. Orfanos (ORCID: https://orcid.org/0000-0002-8229-8562)
- Qi Yang (ORCID: https://orcid.org/0000-0002-8365-0986)
- N. Karmacharya
- Cynthia Koziol‐White (ORCID: https://orcid.org/0000-0003-1101-2747)
- Rennolds S. Ostrom (ORCID: https://orcid.org/0000-0002-7204-0357)
- Reynold A. Panettieri
- A. Ravi (ORCID: https://orcid.org/0000-0002-8661-7145)
Institutions
- Rutgers, The State University of New Jersey (US)
- Chapman University (US)
- Johnson University (US)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1186/s12931-025-03387-3
- Citations
- 1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52