QuYuShengXin formula reshapes bile-acid-mediated macrophage polarization in the treatment of ulcerative colitis
By re-instating the physiologic fecal BA landscape, QYSX engages TGR5 to inhibit NF-κB signaling, thereby suppressing LPS- and TNF-α-driven M1 hyper-activation. This restoration of M2/M1 homeostasis curbs mucosal inflammation and maintains intestinal immune equilibrium, providing a mechanistic rationale for the clinical efficacy of QYSX in UC.
Authors
- Jianjiao Ni (ORCID: https://orcid.org/0000-0003-3113-2586)
- Dan Gan (ORCID: https://orcid.org/0000-0002-6715-0666)
- Jiaqi Jiang (ORCID: https://orcid.org/0009-0001-9896-2579)
- Jiong Wu (ORCID: https://orcid.org/0000-0003-3202-5002)
- Haojie Yang (ORCID: https://orcid.org/0000-0002-8633-2713)
- Can Cui (ORCID: https://orcid.org/0000-0003-4736-4330)
- Yunyun Wang (ORCID: https://orcid.org/0000-0003-2658-1715)
- Zhenyi Wang (ORCID: https://orcid.org/0000-0002-4146-9433)
- Jiaying Tan
- Yuchang Lu
Institutions
- Hunan Normal University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Yueyang Hospital (CN)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1186/s12906-025-05177-2
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80