Review of intraocular lens power calculation formulas in eyes after corneal refractive surgery

The correct post-operative refractive outcome is a crucial aspect of phacoemulsification. Mostly, it relies of effective lens position (ELP) estimation resulting from the selection of appropriate intraocular lens (IOL) power calculation formula. ELP estimation is especially difficult in eyes that have undergone corneal refractive surgery (CRS) since quandaries in achieving an accurate corneal power. It is caused by incorrect measurement of anterior corneal curvature, changes in posterior corneal curvature and aberration of corneal refractive index (1.375). At least several dozen IOL power calculation formulas in eyes with previous CRS have been developed to date. Seventeen the most used formulas were described, and their accuracy was evaluated in this study. The trueness of the formulas was assessed using the mean absolute error (MAE), median absolute error and percentage of eyes with prediction error within ± 0.5 D and ± 1.0 D. In the most studies, Barrett True-K obtained the smallest MAE in previously hyperopic eyes. In previously myopic eyes, Barrett True-K yielded accurate results also, but the Okulix and the Triple-S formulas performed equally well. Thus, Barrett True-K usually achieves the accurate outcomes in IOL power calculation in eyes that have undergone CRS. However, there is still no consensus on the formula choice in post-refractive eyes.

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Publication Details

Journal
Graefe s Archive for Clinical and Experimental Ophthalmology
Published
2025-11-22
DOI
https://doi.org/10.1007/s00417-025-07003-4
Primary Topic
Ophthalmology and Visual Impairment Studies
Type
article
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article

Review of intraocular lens power calculation formulas in eyes after corneal refractive surgery

Wiktor Stopyra, Andrzej E. Grzybowski, Xiangjia Zhu
Graefe s Archive for Clinical and Experimental Ophthalmology
Ophthalmology and Visual Impairment Studies
article

Review of intraocular lens power calculation formulas in eyes after corneal refractive surgery

Wiktor Stopyra, Andrzej E. Grzybowski, Xiangjia Zhu
article en

Abstract

The correct post-operative refractive outcome is a crucial aspect of phacoemulsification. Mostly, it relies of effective lens position (ELP) estimation resulting from the selection of appropriate intraocular lens (IOL) power calculation formula. ELP estimation is especially difficult in eyes that have undergone corneal refractive surgery (CRS) since quandaries in achieving an accurate corneal power. It is caused by incorrect measurement of anterior corneal curvature, changes in posterior corneal curvature and aberration of corneal refractive index (1.375). At least several dozen IOL power calculation formulas in eyes with previous CRS have been developed to date. Seventeen the most used formulas were described, and their accuracy was evaluated in this study. The trueness of the formulas was assessed using the mean absolute error (MAE), median absolute error and percentage of eyes with prediction error within ± 0.5 D and ± 1.0 D. In the most studies, Barrett True-K obtained the smallest MAE in previously hyperopic eyes. In previously myopic eyes, Barrett True-K yielded accurate results also, but the Okulix and the Triple-S formulas performed equally well. Thus, Barrett True-K usually achieves the accurate outcomes in IOL power calculation in eyes that have undergone CRS. However, there is still no consensus on the formula choice in post-refractive eyes.

Graefe s Archive for Clinical and Experimental OphthalmologyVol. 264(2)
Krakow University of Economics (PL), Fudan University (CN), Podhale State Higher Vocational School in Nowy Targ (PL), Foundation for Cardiac Surgery (BE), University of Warmia and Mazury in Olsztyn (PL)
Openalex Percentile: Top 53%
Ophthalmology and Visual Impairment Studies
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Review of intraocular lens power calculation formulas in eyes after corneal refractive surgery — Wiktor Stopyra, Andrzej E. Grzybowski, et al. · Graefe s Archive for Clinical and Experimental Ophthalmology (2025) | TGRS Research Map | TGRS