Integrative analysis of gene expression and histone modifications for DES, DSP, GJA1 and SMOC2 in adipose tissue reveals potential relationship to cardiometabolic health
Depot-specific gene expression of DES, DSP, and SMOC2 in adipose tissue is robustly linked to cardiometabolic traits and supported by distinct epigenetic landscapes in OVAT vs SAT, highlighting their potential as novel biomarkers for cardiometabolic health.
Authors
- Adhideb Ghosh (ORCID: https://orcid.org/0000-0002-5160-4571)
- Yvonne Böttcher
- Anne Hoffmann (ORCID: https://orcid.org/0000-0003-3258-3397)
- Akın Çayır
- Christian Wolfrum (ORCID: https://orcid.org/0000-0002-3862-6805)
- Tina Visnovska (ORCID: https://orcid.org/0000-0003-4920-9756)
- Jon Kristinsson
- Sadia Saeed (ORCID: https://orcid.org/0000-0002-6587-6543)
- Tom Mala (ORCID: https://orcid.org/0000-0003-3058-4775)
- Matthias Blüher (ORCID: https://orcid.org/0000-0003-0208-2065)
- Tobias Hagemann
- Tone Gretland Valderhaug (ORCID: https://orcid.org/0000-0002-9953-7865)
- Stina Ingrid Alice Svensson
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Akershus University Hospital (NO)
- Sykehuset i Vestfold (NO)
- Helmholtz Zentrum München (DE)
- ETH Zurich (CH)
- University Hospital Leipzig (DE)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1186/s10020-025-01391-3
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00