Characterisation of the <i>N</i> ‐Methyltransferase <i>Sg</i> PsmC: Application in the Kinetic Resolution of Pyrroloindolines
Many natural products and pharmaceutical compounds bear the pyrroloindoline scaffold, highlighting the importance of the heterocyclic motif. Here, we aim at expanding the toolset for the selective synthesis of pyrroloindolines by characterising and employing the N-methyltransferase SgPsmC from Streptomyces griseofuscus, an enzyme involved in the biosynthesis of physostigmine, in a selective kinetic resolution of pyrroloindolines performed at a laboratory preparative scale.
Authors
- Birgit Henßen
- Benjamin Panagiotis Chapple
- Sebastian Myllek (ORCID: https://orcid.org/0000-0002-0538-4950)
- Mona Haase (ORCID: https://orcid.org/0009-0008-9773-8138)
- Thomas Claßen (ORCID: https://orcid.org/0000-0002-3259-964X)
- Jörg Pietruszka (ORCID: https://orcid.org/0000-0002-9819-889X)
- Pascal Schneider (ORCID: https://orcid.org/0000-0003-3002-5850)
- Lia Nitz
Institutions
- Forschungszentrum Jülich (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1002/anie.202515459
- Citations
- 1
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81