Translation of a physiologically‐based pharmacokinetic model for dabigatran etexilate to the design of a safety and efficacy study in post‐partum women
An integrated PBPK/PD model for dabigatran etexilate in post-partum women has been developed successfully. The model was used to design a future clinical trial examining safety and efficacy of dabigatran in postpartum women at risk of thromboembolism.
Authors
- Kayode Ogungbenro (ORCID: https://orcid.org/0000-0003-2446-6895)
- Lorna Aucott (ORCID: https://orcid.org/0000-0001-6277-7972)
- Farhad Kamali
- Paul Ayuk
Institutions
- University of Aberdeen (GB)
- Manchester Academic Health Science Centre (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- University of Manchester (GB)
- Newcastle University (GB)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1002/bcp.70344
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00