Short- and long-term associations between antipsychotic treatment patterns and functional outcomes in chronic schizophrenia: A 10-year retrospective study using lagged mixed-effects modeling
Short-term GAF improvement was linked to polypharmacy and use of LAI, whereas higher doses predicted poorer functioning. DUP-based subgroup models showed no significant results overall.
Authors
- Atsuko Nagaoka (ORCID: https://orcid.org/0000-0002-1159-4436)
- Mizuki Hino (ORCID: https://orcid.org/0000-0003-3700-0322)
- Yuhei Mori (ORCID: https://orcid.org/0000-0001-9054-1692)
- Itaru Miura (ORCID: https://orcid.org/0000-0002-2133-5809)
- Masataka Hatano
- Yasuto Kunii (ORCID: https://orcid.org/0000-0003-1569-7819)
- Hiroshi Hoshino (ORCID: https://orcid.org/0000-0001-5755-8126)
- Risa Shishido
- Akiko Satô (ORCID: https://orcid.org/0000-0002-1279-4026)
- Yuto Hosogai
Institutions
- Tohoku Institute of Technology (JP)
- Fukushima Medical University (JP)
- Tohoku University (JP)
Publication Details
- Journal
- Journal of Psychiatric Research
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.jpsychires.2025.11.020
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00