IL-33 confers neuroprotection by activating the ST2/PPAR-γ signaling axis in microglia following subarachnoid in male mice
Our findings demonstrate that IL-33 confers robust neuroprotection against SAH-induced early brain injury by modulating microglial polarization via the PPAR-γ pathway. This positions the IL-33/ST2 axis as a promising novel immunomodulatory strategy for the treatment of SAH.
Authors
- Wenhao Zheng (ORCID: https://orcid.org/0000-0001-5590-6588)
- Bingcheng Zhu
- Zhijin Wang (ORCID: https://orcid.org/0000-0002-7962-2827)
- Zheng Wang (ORCID: https://orcid.org/0000-0003-2781-1746)
- Letian Xue
- Quan Du (ORCID: https://orcid.org/0000-0002-9871-0718)
- Yang Cao (ORCID: https://orcid.org/0000-0002-6625-7605)
Institutions
- Zhejiang Chinese Medical University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108503
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00