Tetrahydrocurcumin Ameliorates Cerebral Ischemia–Reperfusion Injury and Restores Blood–Brain Barrier Dysfunction by Inhibiting Ferroptosis
THC inhibits ferroptosis through the activation of the Keap1/Nrf2 signaling pathway, significantly improving BBB dysfunction and alleviating neurological deficits following cerebral ischemia-reperfusion. These findings suggest that THC could serve as a potential therapeutic agent for ischemic stroke, providing a novel approach for the treatment of cerebral ischemia-reperfusion injury through ferroptosis modulation.
Authors
- Huajiang Deng (ORCID: https://orcid.org/0000-0002-9491-3358)
- Haoxiang Wang (ORCID: https://orcid.org/0000-0002-0361-6527)
- Zhen Fan (ORCID: https://orcid.org/0000-0003-4199-0082)
- Luotong Liu
- Jizhong Han
- Liang Liu (ORCID: https://orcid.org/0000-0002-6773-2324)
- Liangxue Zhou
- Shuang Zhang (ORCID: https://orcid.org/0009-0006-7038-2034)
Institutions
- University of Electronic Science and Technology of China (CN)
- Sichuan University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- West China Hospital of Sichuan University (CN)
- Fourth People's Hospital of Sichuan Province (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1111/cns.70662
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00