Palladium‐Catalyzed Four‐Component Tandem Sulfonylation and Carbonylation of 1,6‐Enynes
A novel palladium‐catalyzed four‐component tandem sulfonylation and carbonylation of 1,6‐enynes has been developed for the rapid construction of succinimide, sulfone, and carbonyl motifs simultaneously. In the presence of very low palladium catalyst loading, the reaction of 1,6‐enynes with nucleophiles proceeded smoothly to afford a wide range of sulfone‐ and carbonyl‐containing succinimide derivatives with high yields and excellent selectivity. Notably, modifications of bioactive molecules were also demonstrated by using this method.
Authors
- Linqi Wang (ORCID: https://orcid.org/0000-0002-5243-341X)
- Jun Ying (ORCID: https://orcid.org/0000-0002-9578-2863)
- Wei Chen (ORCID: https://orcid.org/0000-0001-9527-110X)
- Jing Wang (ORCID: https://orcid.org/0009-0006-3929-9267)
- Jianwei Wang (ORCID: https://orcid.org/0000-0002-6094-376X)
- Yan Cao (ORCID: https://orcid.org/0000-0001-7866-1640)
- Xiaolong Wang (ORCID: https://orcid.org/0000-0003-1620-1344)
Institutions
- Zhejiang Sci-Tech University (CN)
- Sheng Jing Hospital (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1002/adsc.70226
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00