Biogenic Next‐Gen CPL Emitters: Strategies with Proteins, Polysaccharides, and Nucleotides

Abstract Materials and supramolecular structures with the ability to emit circularly polarized luminescence (CPL) are a necessity because they represent an advancement in photonic technologies for encoding, imaging, data manipulation, and chiral catalysis. However, current CPL materials often suffer from low luminescence dissymmetry and brightness, alongside sustainability challenges. This review discusses the emerging potential of biogenic molecules—specifically proteins, peptides, polysaccharides, and nucleotides—as a sustainable and effective strategy to tune and improve the CPL emission of natural or artificial organic chromophores. It highlights their structural advantages, such as hierarchical chirality, structural rigidity, and precise chromophore organization control, which significantly enhance CPL signals. Peptide‐based assemblies are shown to leverage supramolecular interactions and chirality transfer mechanisms to amplify CPL. At the same time, fluorescent proteins utilize chromophore rigidity and exciton coupling to achieve a high CPL brightness. Nucleotide‐based systems further showcase control over chromophore alignment, enabling dynamic and reversible CPL emission. Polysaccharides of different classes provide versatile, chiral scaffolds for inducing CPL through ordered aggregation and templating effects that can also be generated in vivo. Collectively, these biogenic approaches are key candidates for next‐generation CPL‐active materials.