Maternal Folate Receptor Alpha Autoantibodies and Increased Fetal Nuchal Translucency as Potential Early Markers of Autism Spectrum Disorder
FRAA positivity in pregnancies with isolated markedly increased NT may serve as an early biomarker of increased ASD risk in offspring. These findings support the hypothesis of an immune-metabolic mechanism contributing to ASD and suggest potential preventive interventions such as folinic acid supplementation.
Authors
- Francesca Giorlandino
- Claudio Coco (ORCID: https://orcid.org/0000-0002-4713-7093)
- Katia Margiotti (ORCID: https://orcid.org/0000-0003-0432-1525)
- Laura D’Emidio
- Francesca Pignataro (ORCID: https://orcid.org/0000-0003-2772-3308)
- Alvaro Mesoraca (ORCID: https://orcid.org/0009-0000-6954-6392)
- Marco Fabiani (ORCID: https://orcid.org/0000-0002-8763-0114)
- Marina Cupellaro
- Raffaella Raffio
- Concetta De Pasquale (ORCID: https://orcid.org/0000-0003-4692-0980)
- Vincenzo Milite
- Claudio Giorlandino (ORCID: https://orcid.org/0000-0002-8448-7260)
- Maria Luisa Mastrandrea
Institutions
- AltaMed (US)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/brb3.71088
- Citations
- 2
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86