Estrogen receptor expression by immunohistochemistry is not specific to gynecologic-type smooth muscle
ER expression may be present in both neoplastic and non-neoplastic smooth muscle at non-gynecologic sites. Extra-gynecologic leiomyosarcoma arising in female patients and from retroperitoneum/pelvic vasculature are more likely to show ER expression compared to male patients and other non-gynecologic sites, respectively. These findings limit the utility of ER expression in determining the site of origin when evaluating smooth muscle neoplasms of the pelvis and retroperitoneum.
Authors
- Mariya Farooqui (ORCID: https://orcid.org/0000-0002-2136-8694)
- Rayan Sibira (ORCID: https://orcid.org/0000-0002-2468-2371)
- Karin Daniels (ORCID: https://orcid.org/0000-0003-0204-3285)
- Anna Vu
- Josephine K. Dermawan (ORCID: https://orcid.org/0000-0002-1139-2914)
- Karen J. Fritchie (ORCID: https://orcid.org/0009-0009-3831-7496)
- Yan Zhou (ORCID: https://orcid.org/0000-0003-3379-2369)
Institutions
- University of Minnesota (US)
- Fairview Health Services (US)
- Cleveland Clinic (US)
Publication Details
- Journal
- Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1007/s00428-025-04300-5
- Primary Topic
- Uterine Myomas and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00