A novel regulatory circuit of ATG4B and SESN3 promotes T cell leukemogenesis
The present study demonstrates that a novel ATG4B-SESN3 regulatory circuit plays a crucial role in T cell leukemogenesis, which suggests that targeting ATG4B is a promising strategy for T-ALL treatment.
Authors
- Xiuyan Zhang
- Wenjuan Ma (ORCID: https://orcid.org/0000-0002-7739-4891)
- Xiaoyan Jiang (ORCID: https://orcid.org/0000-0002-1968-6810)
- Hong Liu (ORCID: https://orcid.org/0000-0002-8926-1308)
- Rongyao Ma
- Yan Wan (ORCID: https://orcid.org/0000-0002-7712-7531)
- Xiao Qin (ORCID: https://orcid.org/0000-0003-3603-3341)
- Bo Hu (ORCID: https://orcid.org/0000-0001-9213-1304)
- Lei Zhang (ORCID: https://orcid.org/0000-0002-0045-6863)
- Xiang Song (ORCID: https://orcid.org/0000-0003-0235-3734)
- Haixia Zhou (ORCID: https://orcid.org/0009-0001-5309-5715)
- Xiaonan Zhou
- Jianrong Wang
- Yun Zhao
- Depei Wu (ORCID: https://orcid.org/0009-0003-3176-9963)
Institutions
- Soochow University (CN)
- Terry Fox Research Institute (CA)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1186/s13046-025-03588-0
- Primary Topic
- T-cell and Retrovirus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00