Single-cell and spatial transcriptomics reveal lactylation-associated tumor cell clusters and define a prognostic risk model in glioblastoma

Lactylation defines distinct tumor cell clusters in GBM that are spatially localized, metabolically reprogrammed, and immunosuppressive. The S100A6-associated lactylation signature serves as a robust prognostic biomarker and potential therapeutic target in GBM.

Authors

Ziran Xu (ORCID: https://orcid.org/0000-0002-6412-7583)
Rui Han (ORCID: https://orcid.org/0000-0001-8856-3681)
Kan Xu (ORCID: https://orcid.org/0000-0001-8947-1172)
Liangfu Zhou (ORCID: https://orcid.org/0000-0001-6808-7120)
Dongjie Sun (ORCID: https://orcid.org/0009-0005-2951-5213)
Guangfan Chi

Institutions

Jilin University (CN)
First Hospital of Jilin University (CN)
Jilin Medical University (CN)

Publication Details

Journal: BMC Cancer
Published: 2025-11-22
DOI: https://doi.org/10.1186/s12885-025-15291-6
Citations: 2
Primary Topic: Immune cells in cancer
Type: article
Field-Weighted Citation Impact: 1.59

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article

Single-cell and spatial transcriptomics reveal lactylation-associated tumor cell clusters and define a prognostic risk model in glioblastoma

Ziran Xu, Rui Han, Kan Xu, Liangfu Zhou et al.

Nov 22, 2025

2 citations

BMC Cancer

Immune cells in cancer

1.59

article

Single-cell and spatial transcriptomics reveal lactylation-associated tumor cell clusters and define a prognostic risk model in glioblastoma

Ziran Xu, Rui Han, Kan Xu, Liangfu Zhou, Dongjie Sun, Guangfan Chi

November 22, 2025article en

2 citations

Abstract

Lactylation defines distinct tumor cell clusters in GBM that are spatially localized, metabolically reprogrammed, and immunosuppressive. The S100A6-associated lactylation signature serves as a robust prognostic biomarker and potential therapeutic target in GBM.

BMC CancerVol. 25(1)

Jilin University (CN), First Hospital of Jilin University (CN), Jilin Medical University (CN)

Openalex Percentile: Top 14%

Immune cells in cancer

1.59

DOI Open Access PDF OpenAlex

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Single-cell and spatial transcriptomics reveal lactylation-associated tumor cell clusters and define a prognostic risk model in glioblastoma — Ziran Xu, Rui Han, et al. · BMC Cancer (2025) | TGRS Research Map | TGRS