The P4HA1/HIF1α feedback loop modulates endothelial dysfunction in pulmonary hypertension
Our studty identify P4HA1 as a novel contributor to PH pathogenesis and suggest that targeting the P4HA1/HIF1α axis may offer a promising therapeutic approach for pulmonary hypertension.
Authors
- Shao‐Liang Chen (ORCID: https://orcid.org/0000-0003-3219-5941)
- Yunwei Chen (ORCID: https://orcid.org/0000-0002-5144-925X)
- Zhiyuan Qian (ORCID: https://orcid.org/0000-0002-7674-057X)
- Chaohua Kong (ORCID: https://orcid.org/0000-0001-7854-0718)
- Yunfei Deng (ORCID: https://orcid.org/0000-0002-1327-724X)
- Yue Gu
- Zihao Jiang
- Xiaomin Jiang
- Meng Yang (ORCID: https://orcid.org/0000-0002-5520-0654)
- Yifei Lv (ORCID: https://orcid.org/0000-0002-8211-4372)
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1186/s12931-025-03419-y
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00