Enzymatic Drivers of Cartilage Breakdown: Insights From a Bovine Osteoarthritis Explant Model
This chemically induced bovine model successfully simulates early cartilage degeneration consistent with OA pathology. Supported by recent literature on the roles of MMPs, ADAMTS-5, and COMP in joint disease, the model offers a valuable platform for future studies on OA mechanisms and therapeutic screening.
Authors
- Ahmed Suparno Bahar Moni (ORCID: https://orcid.org/0000-0002-6434-5679)
- Adrian Lawrence
- Katie Beier
- Joseph Boesel
- Hayes Unrein
- Lucas Ratiani
Institutions
- University of Toledo (US)
Publication Details
- Journal
- Orthopaedic Surgery
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1111/os.70202
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00