Ingestion of Isobutyl Nitrite Leading to Methemoglobinemia: A Case Report

This case report highlights an occurrence of methemoglobinemia caused by the ingestion of liquid amyl nitrite, a substance often misused as a recreational drug. The patient in this case presented with cyanosis and elevated methemoglobin levels. Prompt administration of methylene blue successfully reversed the methemoglobinemia by reducing methemoglobin back to hemoglobin. This case emphasizes the importance of rapid diagnosis and treatment in nitrite-induced methemoglobinemia, demonstrating methylene blue as a highly effective antidote. It also highlights the risks associated with amyl nitrite misuse and the crucial role of healthcare providers in managing this potentially life-threatening condition.

Authors

Institutions

Publication Details

Journal
Cureus
Published
2025-11-21
DOI
https://doi.org/10.7759/cureus.97471
Primary Topic
Methemoglobinemia and Tumor Lysis Syndrome
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Ingestion of Isobutyl Nitrite Leading to Methemoglobinemia: A Case Report

Douglas R. Dixon, Mohammed Atiqur Rahman, Hanna Nour, Larissa Dub
Cureus
Methemoglobinemia and Tumor Lysis Syndrome
article

Ingestion of Isobutyl Nitrite Leading to Methemoglobinemia: A Case Report

Douglas R. Dixon, Mohammed Atiqur Rahman, Hanna Nour, Larissa Dub
article en

Abstract

This case report highlights an occurrence of methemoglobinemia caused by the ingestion of liquid amyl nitrite, a substance often misused as a recreational drug. The patient in this case presented with cyanosis and elevated methemoglobin levels. Prompt administration of methylene blue successfully reversed the methemoglobinemia by reducing methemoglobin back to hemoglobin. This case emphasizes the importance of rapid diagnosis and treatment in nitrite-induced methemoglobinemia, demonstrating methylene blue as a highly effective antidote. It also highlights the risks associated with amyl nitrite misuse and the crucial role of healthcare providers in managing this potentially life-threatening condition.

CureusVol. 17(11)
University of Central Florida (US), Osceola Regional Medical Center (US), AdventHealth Kissimmee (US)
HCA Healthcare
Openalex Percentile: Top 49%
Methemoglobinemia and Tumor Lysis Syndrome
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Ingestion of Isobutyl Nitrite Leading to Methemoglobinemia: A Case Report — Douglas R. Dixon, Mohammed Atiqur Rahman, et al. · Cureus (2025) | TGRS Research Map | TGRS