DNA-Compatible Synthesis of α-Aminophosphonate Scaffolds via Kabachnik–Fields Reaction
In this study, we report a DNA-compatible synthetic approach for the construction of α-aminophosphonate derivatives─phosphorus-containing bioisosteres of α-amino acids─via the Kabachnik-Fields reaction. This multicomponent transformation proceeds under mild conditions, demonstrates a broad substrate scope, and exhibits excellent compatibility with subsequent enzymatic ligation. Its successful application to a mock library synthesis further underscores the potential of this method as a valuable addition to the toolbox of DEL-compatible chemistry.
Authors
- Hyewon Seo (ORCID: https://orcid.org/0000-0002-2734-7050)
- In Young Choi (ORCID: https://orcid.org/0000-0002-2860-9411)
- Gil Tae Hwang (ORCID: https://orcid.org/0000-0001-7107-9244)
- Minsoo Song (ORCID: https://orcid.org/0000-0002-2136-4618)
- Jihoon Lee (ORCID: https://orcid.org/0000-0001-5327-824X)
- Ki Tae Kim (ORCID: https://orcid.org/0000-0003-2479-6093)
Institutions
- Chungbuk National University (KR)
- Kyungpook National University (KR)
- Korea Basic Science Institute (KR)
- International Drug Development (FR)
- Daegu-Gyeongbuk Medical Innovation Foundation (KR)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1021/acs.orglett.5c04477
- Citations
- 2
- Primary Topic
- Organophosphorus compounds synthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.87