Neuroinflammation PET and long-term cognition and survival in symptomatic Alzheimer’s disease
Contrary to our hypothesis, we did not find evidence for [<sup>11</sup>C]PK11195 PET predicting long-term cognitive decline or survival. This may indicate that the level of [<sup>11</sup>C]PK11195 PET binding earlier in the disease trajectory is not directly linked to the long-term outcome.
Authors
- Albert D. Windhorst (ORCID: https://orcid.org/0000-0002-1250-7656)
- Roos M. Rikken (ORCID: https://orcid.org/0000-0002-1357-2572)
- Ellen Dicks (ORCID: https://orcid.org/0000-0003-2496-1626)
- Ronald Boellaard (ORCID: https://orcid.org/0000-0002-0313-5686)
- Emma M. Coomans (ORCID: https://orcid.org/0000-0002-4289-9101)
- Elsmarieke van de Giessen
- Annelies E. van der Vlies
- Everard G.B. Vijverberg (ORCID: https://orcid.org/0000-0003-3879-884X)
- Yolande A.L. Pijnenburg (ORCID: https://orcid.org/0000-0003-2464-1905)
- Maqsood Yaqub
Institutions
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1186/s13195-025-01915-3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- National Cancer Institute