DHX9 aggravates epilepsy by promoting STAT1 phosphorylation to increase oxidative stress and apoptosis
This study reveals the important role of DHX9 in epilepsy pathogenesis and elucidates the molecular mechanism by which DHX9 directly interacts with STAT1 and promotes its phosphorylation, thereby activating downstream oxidative stress and apoptotic signaling pathways, ultimately aggravating epileptic neuronal injury.
Authors
- Qi Song (ORCID: https://orcid.org/0000-0002-1167-871X)
- Daxiong Feng (ORCID: https://orcid.org/0000-0002-4333-6159)
- Hong Chen (ORCID: https://orcid.org/0000-0001-8054-7417)
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111650
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00