Ceramide levels predict clinical severity in adult-onset Krabbe disease independent of extensive white matter hyperintensities
Extensive white matter hyperintensity is a characteristic radiological feature of adult-onset Krabbe disease. PSY levels cannot serve as biomarker of adult-onset KD. Elevated plasma ceramides and sphingosine warrant exploration as candidate biomarkers of disease severity.
Authors
- Junyi Jiang (ORCID: https://orcid.org/0000-0002-4080-069X)
- Boli Chen
- Shuna Huang (ORCID: https://orcid.org/0000-0002-5420-0150)
- Dandan Zuo
- Wan‐Jin Chen (ORCID: https://orcid.org/0000-0002-9472-8494)
- Anqi Wang (ORCID: https://orcid.org/0000-0002-7182-5427)
- Ying Liu (ORCID: https://orcid.org/0000-0001-7710-0809)
- Qinghua Wang (ORCID: https://orcid.org/0000-0003-3912-3174)
- Xiang Lin (ORCID: https://orcid.org/0000-0002-1449-0114)
- Junhao Xie (ORCID: https://orcid.org/0009-0003-0805-0424)
- Xinyu Yan (ORCID: https://orcid.org/0000-0001-7558-0626)
- Shen Lin (ORCID: https://orcid.org/0000-0003-3901-9393)
- Jianpeng Zhu (ORCID: https://orcid.org/0009-0001-5620-231X)
- Chunyan Cao
Institutions
- Fujian Medical University (CN)
- Army Medical University (CN)
- Zhengzhou University (CN)
- Daping Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.nbd.2025.107202
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00