Impact of Dupilumab for Severe Asthma on Fatigue, Quality of Life, Work Productivity, and Activity
Fatigue, QoL, and work and activity impairment improved following dupilumab initiation, though most patients did not achieve clinically relevant improvements. Effects on fatigue and work and activity impairment appear less pronounced compared with asthma symptom control, possibly due to irreversible impairments in some patients.
Authors
- Anneke Ten Brinke (ORCID: https://orcid.org/0000-0002-7890-1584)
- Simone Hashimoto (ORCID: https://orcid.org/0000-0001-8995-3817)
- Jacob K. Sont (ORCID: https://orcid.org/0000-0002-5840-0651)
- Arnoud F Aldenkamp
- Astrid van Huisstede (ORCID: https://orcid.org/0000-0002-3066-492X)
- Jeroen M.A.M. Retera
- Marijke Amelink
- Kim de Jong (ORCID: https://orcid.org/0000-0002-3948-1046)
- Karen T.M. Oud
- Johannes A. Kroes (ORCID: https://orcid.org/0000-0002-9418-4861)
- Fleur L. Meulmeester (ORCID: https://orcid.org/0000-0002-8910-9795)
- Thomas Macken
- Kornelis W. Patberg
- Karin B. Fieten (ORCID: https://orcid.org/0000-0003-3790-7581)
- Gert‐Jan Braunstahl (ORCID: https://orcid.org/0000-0001-7671-3742)
- Els J.M. Weersink (ORCID: https://orcid.org/0000-0001-7146-1398)
- L. Havé (ORCID: https://orcid.org/0000-0002-9196-706X)
- Annelies Beukert
- Edwin van Velzen
- Lennart Conemans (ORCID: https://orcid.org/0000-0002-2348-1826)
- Marjo J.T. van de Ven
- Sarah Bendien (ORCID: https://orcid.org/0000-0003-2069-9181)
- Ilonka H. van Veen
- Pieter-Paul Hekking
- Lotte van Ruitenbeek
Institutions
- Radboud University Nijmegen (NL)
- Fryske Akademy (NL)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Catharina Ziekenhuis (NL)
- Medisch Spectrum Twente (NL)
- Medisch Centrum Leeuwarden (NL)
- Maastricht University (NL)
- Sint Franciscus Gasthuis (NL)
- Spaarne Ziekenhuis (NL)
- Northwest Hospital (US)
- Amsterdam Neuroscience (NL)
- Ziekenhuis Gelderse Vallei (NL)
- Nederlands Astmacentrum Davos (CH)
- Haga Hospital (NL)
- Isala (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Ziekenhuis Groep Twente (NL)
- Franciscus Vlietland (NL)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- Deventer Ziekenhuis (NL)
- Meander Medisch Centrum (NL)
- Jeroen Bosch Ziekenhuis (NL)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- The Journal of Allergy and Clinical Immunology In Practice
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.jaip.2025.11.015
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca
- Sanofi
- Teva Pharmaceutical Industries
- European Respiratory Society
- ZonMw