Overweight Impairs Escalating Optimal Methotrexate Dose and Effect via Liver Dysfunction in Japanese Patients With Rheumatoid Arthritis
Overweight was associated with reduced MTX response in Japanese RA patients, potentially due to elevated liver enzymes limiting MTX dose escalation and leading to suboptimal dosing per body weight. Weight management and lifestyle interventions may improve treatment outcomes in overweight RA patients.
Authors
- Toshiharu Saito
- Shunichi Kumagai (ORCID: https://orcid.org/0000-0002-0352-7903)
- S. Takahashi (ORCID: https://orcid.org/0000-0002-8515-0563)
- Saori Hatachi
- Miho Shibata
- Miho Takahashi (ORCID: https://orcid.org/0000-0001-8579-0109)
- A. Mori (ORCID: https://orcid.org/0000-0002-4924-1724)
Institutions
- Shinko Hospital (JP)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1111/1756-185x.70487
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00