High HBV seroprotection rates in infants born to people with HIV and HBV infection in sub-Saharan Africa
There is little data on hepatitis B surface antibody (anti-HBs) responses in HIV-exposed, uninfected (HEU) infants born to people living with HIV and hepatitis B virus infection (HBV) (HEU-HBV). We examined anti-HBs titers in infants in a post-hoc analysis of the HIV Prevention Trials Network (HPTN) 046 trial. Thirty-three infants were tested for anti-HBs at 6 and 12 months. Of these, 84.8 % had a protective response (anti-HBs >10 IU/ml) at 6 months, and 97 % had anti-HBs >10 IU/ml at 12 months. Infants with low birth weight ([LBW] ≤2500 g) had lower median anti-HBs titers at 6 and 12 months (472 IU/mL and 48 IU/mL, respectively) compared to infants without LBW, although this was not statistically significant. Anti-HBs titers at 6 and 12 months in HEU-HBV are similar to those in HIV unexposed, uninfected (HUU) infants.
Authors
- Tsungai Chipato (ORCID: https://orcid.org/0009-0001-3629-3429)
- Yvonne Maldonado (ORCID: https://orcid.org/0000-0002-5664-5583)
- Rong Guo (ORCID: https://orcid.org/0000-0003-2799-3463)
- Tian-hao Zhang (ORCID: https://orcid.org/0000-0002-4422-5581)
- Chi‐Hong Tseng (ORCID: https://orcid.org/0000-0002-6542-5195)
- Dhayendre Moodley (ORCID: https://orcid.org/0000-0003-1849-9631)
- Kenneth Kintu
- Lynda Stranix‐Chibanda (ORCID: https://orcid.org/0000-0003-3566-1688)
- Karim Manji (ORCID: https://orcid.org/0000-0002-7069-6408)
- Shih-Hsin Chiu
- Chloe L. Thio (ORCID: https://orcid.org/0000-0002-8851-8319)
- Neaka Mohtashemi
- Lynda Emel (ORCID: https://orcid.org/0000-0002-4929-9862)
- Hannah Ship (ORCID: https://orcid.org/0000-0003-3031-9197)
- Mary Catherine Cambou (ORCID: https://orcid.org/0000-0003-2527-2574)
- Judith S. Currier (ORCID: https://orcid.org/0000-0003-4279-4737)
- Debika Bhattacharya (ORCID: https://orcid.org/0000-0002-2136-7763)
- Julia Spaczai
Institutions
- Johns Hopkins University (US)
- University of Zimbabwe (ZW)
- Muhimbili University of Health and Allied Sciences (TZ)
- University of California, Los Angeles (US)
- Johns Hopkins Medicine (US)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Fred Hutch Cancer Center (US)
- MUJHU Research Collaboration (UG)
- University of KwaZulu-Natal (ZA)
- Stanford University (US)
Publication Details
- Journal
- Vaccine X
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.jvacx.2025.100759
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00