Impaired placental vascular remodeling and persistent uNK cells in the RUPP model: A time-dependent perspective
While gross placental structure remains intact in the RUPP model, the key functional adaptations uNK cell migration, trophoblast invasion, and vascular remodeling, are impaired. These findings support the RUPP as a relevant model to study the pathophysiological mechanisms of placental insufficiency. Future research should focus on temporal molecular profiling to elucidate the mechanisms behind impaired uNK cell retention and shallow trophoblast invasion.
Authors
- Raymond M. Schiffelers (ORCID: https://orcid.org/0000-0002-1012-9815)
- Fieke Terstappen (ORCID: https://orcid.org/0000-0002-6587-1320)
- Marijke M. Faas (ORCID: https://orcid.org/0000-0002-5860-3993)
- A. Titia Lely (ORCID: https://orcid.org/0000-0001-6356-7707)
- G.J. Strijkers
- Fatimah M. Al Darwish (ORCID: https://orcid.org/0000-0002-1011-2669)
- Bram F. Coolen (ORCID: https://orcid.org/0000-0003-3946-653X)
- Caren M. van Kammen (ORCID: https://orcid.org/0000-0001-8454-3851)
- Lindy K. Alles
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Utrecht University (NL)
- Wilhelmina Children's Hospital (NL)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Placenta
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.placenta.2025.11.008
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw