Gypenoside XVII regulates apoptosis and fear extinction deficits mediated by post-traumatic stress disorder through the PERK/CHOP signaling pathway
GP-17 demonstrates therapeutic potential for PTSD by modulating fear and anxiety in SPS rats through the PERK/CHOP pathway, positioning it as a promising candidate for PTSD treatment via the endoplasmic reticulum stress pathway.
Authors
- Yueyang Chen (ORCID: https://orcid.org/0000-0002-4390-550X)
- Zemeng Li
- Dianxu Ren (ORCID: https://orcid.org/0000-0002-1160-8922)
- Hongtao Sun (ORCID: https://orcid.org/0000-0002-8454-806X)
- Wei Li
- Huimin Zhang (ORCID: https://orcid.org/0000-0002-7343-5641)
- Jingjing Wang (ORCID: https://orcid.org/0000-0002-8167-7480)
- Shuying Wang (ORCID: https://orcid.org/0000-0001-7107-7636)
- Yifei Yang (ORCID: https://orcid.org/0000-0001-9809-1534)
- Pengbo Zhou
Institutions
- Chinese People's Armed Police Force Medical College Affiliated Hospital (CN)
- Logistics University of People's Armed Police Force (CN)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.ejphar.2025.178391
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00