Chronic kidney disease and denosumab in metastatic bone disease: A multicenter Turkish cohort study on severe hypocalcemia, skeletal events, and survival
Cancer patients with CKD receiving denosumab have an increased risk of severe hypocalcaemia and skeletal complications. Close monitoring of calcium and renal function is essential, and clinicians should carefully balance the benefits of denosumab against these risks in this vulnerable population.
Authors
- Özkan Alan (ORCID: https://orcid.org/0000-0002-6635-2012)
- Hüseyin Salih Semiz (ORCID: https://orcid.org/0000-0002-7083-8517)
- Yusuf İlhan (ORCID: https://orcid.org/0000-0002-2875-6876)
- Halil İbrahim Ellez (ORCID: https://orcid.org/0000-0002-9593-0942)
- Atike Pınar Erdoğan (ORCID: https://orcid.org/0000-0003-4859-7574)
- Havva Yeşil Çınkır (ORCID: https://orcid.org/0000-0002-7870-8741)
- Teoman Şakalar (ORCID: https://orcid.org/0000-0003-2749-9414)
- Fatih Kuş (ORCID: https://orcid.org/0000-0003-1650-154X)
- Naziye Ak (ORCID: https://orcid.org/0000-0001-5790-7066)
- Nazım Serdar Turhal (ORCID: https://orcid.org/0000-0002-1013-5676)
- Kubilay Karaboyun (ORCID: https://orcid.org/0000-0002-1783-8075)
- Ertuğrul Bayram (ORCID: https://orcid.org/0000-0001-8713-7613)
- Melike Özçelik (ORCID: https://orcid.org/0000-0003-0406-715X)
- Yakup Düzköprü (ORCID: https://orcid.org/0000-0003-2314-5870)
- Ferhat Ekinci (ORCID: https://orcid.org/0000-0002-9317-942X)
- Melek Karakurt Eryılmaz (ORCID: https://orcid.org/0000-0003-2597-5931)
- Tuğba Yavuzşen (ORCID: https://orcid.org/0000-0001-9375-8133)
- Fatih Karataş (ORCID: https://orcid.org/0000-0003-4022-7923)
- Nilgün Yıldırım (ORCID: https://orcid.org/0000-0001-8198-2605)
- Esma Türkmen Bekmez
Institutions
- Aksaray University (TR)
- Koç University (TR)
- Manisa Celal Bayar University (TR)
- Shimane University (JP)
- Karabük University (TR)
- Dokuz Eylül University (TR)
- Necmettin Erbakan University (TR)
- Antalya Eğitim ve Araştırma Hastanesi (TR)
- Ümraniye Eğitim ve Araştırma Hastanesi (TR)
- Education Training And Research (US)
- Sağlık Bilimleri Üniversitesi (TR)
- Antalya IVF (TR)
- Kahramanmaraş Sütçü İmam University (TR)
- Kocaeli Üniversitesi (TR)
- Burdur Mehmet Akif Ersoy Üniversitesi (TR)
- Cukurova University (TR)
- Gaziantep University (TR)
- Hacettepe University (TR)
- Istanbul University (TR)
Publication Details
- Journal
- Journal of bone oncology
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.jbo.2025.100730
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00