Mouse neuronal dendritic complexity and resilience to stress-induced depression in Drosophila melanogaster are enhanced by Withania somnifera alkaloids
These findings highlight a role for alkaloids, including acetyltropine, as potential active constituents of WS associated with neuroprotective and anti-stress effects traditionally attributed to this plant. Results support continued evaluation of additional WS active compounds beyond withanolides.
Authors
- Claudia S. Maier (ORCID: https://orcid.org/0000-0003-0743-8956)
- Md Nure Alam (ORCID: https://orcid.org/0000-0001-7579-2346)
- Mikah S. Brandes (ORCID: https://orcid.org/0000-0003-0892-1608)
- Jonathan A. Zweig (ORCID: https://orcid.org/0000-0002-7015-9821)
- Jan F. Stevens (ORCID: https://orcid.org/0000-0002-6348-9347)
- Jaewoo Choi (ORCID: https://orcid.org/0000-0001-6376-3089)
- R. Dutta
- Liping Yang (ORCID: https://orcid.org/0000-0002-9011-0443)
- Burkhard Poeck
- Amala Soumyanath (ORCID: https://orcid.org/0000-0003-1569-6453)
- Cody J. Neff
- Roland Strauß
- Nora E. Gray (ORCID: https://orcid.org/0000-0001-6848-859X)
- Christine McClure
- Luke Marney (ORCID: https://orcid.org/0000-0001-8117-8246)
- Kadine Cabey
- Doris Kretzschmar (ORCID: https://orcid.org/0000-0002-0519-2377)
- Helen Holvoet
- Jesús Miñano Martínez
Institutions
- Oregon State University (US)
- Oregon Health & Science University (US)
- Johannes Gutenberg University Mainz (DE)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.jep.2025.120905
- Primary Topic
- Phytochemicals and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00