Does surgical history matter? A register-based study of 94 000 individuals from the Swedish osteoarthritis register on clinical profiles and outcomes of first-line treatment for knee osteoarthritis

The findings suggest that individuals with knee OA and a history of prior knee surgery may represent a specific clinical phenotype, characterized by a younger age, male sex, and higher levels of physical activity when entering first-line treatment. Despite positive treatment responses in both groups, individuals with a history of surgery more often reported ongoing clinical features at the 3-month follow-up.