Associations of Blood Mitochondrial DNA Quality and Quantity with Risk of Kidney Function Decline
In older community-dwelling adults, higher mtDNA heteroplasmy was associated with a higher risk of kidney function decline, while higher mtDNA-CN was associated with a lower risk of kidney function decline. These findings expand the measures of mitochondrial health that may provide insight into kidney disease progression and warrant exploration in higher-risk populations.
Authors
- Gregory J. Tranah (ORCID: https://orcid.org/0000-0002-5520-812X)
- Wen Shi (ORCID: https://orcid.org/0000-0002-2886-2361)
- Ronit Katz (ORCID: https://orcid.org/0000-0001-7723-7469)
- Joachim H. Ix (ORCID: https://orcid.org/0000-0002-8084-9869)
- Samir M. Parikh (ORCID: https://orcid.org/0000-0002-1038-981X)
- Meghana Eswarappa (ORCID: https://orcid.org/0000-0002-4839-4809)
- Chirag R. Parikh (ORCID: https://orcid.org/0000-0001-9051-7385)
- Dan E. Arking (ORCID: https://orcid.org/0000-0001-8980-8695)
- Charles Newcomb (ORCID: https://orcid.org/0000-0002-2646-7288)
- Sushrut S. Waikar (ORCID: https://orcid.org/0000-0003-4004-326X)
- Vasantha Jotwani (ORCID: https://orcid.org/0000-0003-1913-3957)
- Michael G. Shlipak (ORCID: https://orcid.org/0000-0002-9559-204X)
- Steve Cummings
Institutions
- Boston University (US)
- Boston Medical Center (US)
- Tufts Medical Center (US)
- Johns Hopkins University (US)
- University of California, San Francisco (US)
- University of Washington (US)
- Johns Hopkins Medicine (US)
- California Pacific Medical Center (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- San Francisco VA Health Care System (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Clinical Journal of the American Society of Nephrology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.2215/cjn.0000000893
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00