The Role of IL-12 Family Cytokines in the Pathogenesis of Periodontal Disease: A Therapeutic Approach
Members of the IL-12 cytokine family exert both pathogenic and protective influences in periodontal disease. Therapeutic strategies that suppress IL-12/IL-23-driven inflammation while augmenting IL-27/IL-35-mediated regulation show promise as host-modulatory approaches in periodontal treatment. A deeper understanding of these immunologic dynamics may advance precision-based periodontal therapies.
Authors
- Haichao Wang (ORCID: https://orcid.org/0000-0001-6551-908X)
- Hongyi Zhang
Institutions
- Yangtze University (CN)
- First People's Hospital of Jingzhou (CN)
Publication Details
- Journal
- Immunological Investigations
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1080/08820139.2025.2590612
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00