Nitric Oxide to Reduce Acute Kidney Injury in Patients with Preexisting Endothelial Dysfunction Requiring Prolonged Cardiopulmonary Bypass: A Randomized Clinical Trial
In cardiac surgery patients with preexisting endothelial dysfunction undergoing prolonged CPB, perioperative administration of 80 ppm nitric oxide for 24 h did not significantly reduce postoperative AKI. These findings do not support the routine use of nitric oxide in this patient population.
Authors
- Valentina Giammatteo
- Naman S. Shetty (ORCID: https://orcid.org/0000-0003-3600-126X)
- Binglan Yu (ORCID: https://orcid.org/0000-0001-5496-2131)
- Bruce Thompson (ORCID: https://orcid.org/0000-0002-5885-0652)
- Francesco Marrazzo (ORCID: https://orcid.org/0000-0001-5407-6615)
- Oluwaseun Akeju
- Kenneth G. Shann (ORCID: https://orcid.org/0000-0002-1488-5124)
- Hui Zheng (ORCID: https://orcid.org/0000-0001-6725-1910)
- Thoralf M. Sundt (ORCID: https://orcid.org/0000-0002-0409-7028)
- Martin Feelisch (ORCID: https://orcid.org/0000-0003-2320-1158)
- Bijan Safaee Fakhr (ORCID: https://orcid.org/0000-0002-2841-1413)
- Francesco Zadek (ORCID: https://orcid.org/0000-0002-2377-3992)
- Stefano Gianni (ORCID: https://orcid.org/0000-0002-0838-3654)
- Carolyn La Vita
- Fumito Ichinose (ORCID: https://orcid.org/0000-0003-4535-1632)
- Stefano Spina (ORCID: https://orcid.org/0000-0003-3210-1714)
- Pankaj Arora (ORCID: https://orcid.org/0000-0003-2420-3550)
- Lorenzo Berra (ORCID: https://orcid.org/0000-0003-2702-2093)
- Raffaele Di Fenza (ORCID: https://orcid.org/0000-0002-5675-7139)
- Joseph Vincent Bonventre (ORCID: https://orcid.org/0000-0001-7144-386X)
- Mokshad Gaonkar (ORCID: https://orcid.org/0000-0003-0309-6813)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Alabama at Birmingham (US)
- Massachusetts General Hospital (US)
- Birmingham VA Medical Center (US)
- University of Southampton (GB)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1097/aln.0000000000005861
- Citations
- 1
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.16