Proteomics-based clustering outperforms clinical clustering in identifying people with heart failure with distinct outcomes
Proteomics-based clustering identifies three HFrEF clusters associated with distinct outcomes that remain undetected using only clinical characteristics.
Authors
- Kadir Çalişkan (ORCID: https://orcid.org/0000-0002-3293-9261)
- Amand F. Schmidt (ORCID: https://orcid.org/0000-0003-1327-0424)
- Jessica van Setten (ORCID: https://orcid.org/0000-0002-4934-7510)
- Teun B. Petersen (ORCID: https://orcid.org/0000-0002-2338-9931)
- David E. Lanfear (ORCID: https://orcid.org/0000-0001-6471-1483)
- Victor A. Umans (ORCID: https://orcid.org/0000-0002-5587-9097)
- K. Martijn Akkerhuis (ORCID: https://orcid.org/0000-0003-4833-3130)
- Jan van Ramshorst (ORCID: https://orcid.org/0000-0002-0951-8661)
- Isabella Kardys (ORCID: https://orcid.org/0000-0002-2115-9745)
- Olivier C. Manintveld (ORCID: https://orcid.org/0000-0002-2202-7314)
- Marie de Bakker (ORCID: https://orcid.org/0000-0002-4883-2805)
- Alicia Uijl (ORCID: https://orcid.org/0000-0003-2835-7741)
- Dimitris Rizopoulos (ORCID: https://orcid.org/0000-0001-9397-0900)
- Eric H. Boersma (ORCID: https://orcid.org/0000-0002-2559-7128)
- Marion van Vugt (ORCID: https://orcid.org/0000-0002-6634-1989)
- Folkert W Asselbergs
- Ruicong She (ORCID: https://orcid.org/0000-0002-5087-9362)
Institutions
- Utrecht University (NL)
- Erasmus MC (NL)
- Henry Ford Hospital (US)
- Karolinska Institutet (SE)
- University Medical Center Utrecht (NL)
- British Heart Foundation (GB)
- National Institute for Health and Care Research (GB)
- Stockholm South General Hospital (SE)
- Northwest Hospital (US)
- Netherlands Heart Institute (NL)
- Health Data Research UK (GB)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1038/s43856-025-01213-x
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Federation of Pharmaceutical Industries and Associations
- Government of the United Kingdom
- UK Research and Innovation
- National Institute for Health and Care Research
- British Heart Foundation
- University College London
- Rosetrees Trust
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Jaap Schouten Foundation
- National Institutes of Health
- HORIZON EUROPE Framework Programme