Mn-Catalyzed Asymmetric Transfer Hydrogenation of Ketones Improved by Cinchona Alkaloid-Derived NNS Ligands
A novel class of phosphine-free manganese catalysts incorporating cinchona alkaloid-derived NNS ligands (<b>L1</b>-<b>L8</b>) has been successfully developed for asymmetric transfer hydrogenation (ATH). Among these, manganese complex Mn(CO)<sub>3</sub>(<b>L1</b>)Br demonstrated remarkable catalytic performance in the transfer hydrogenation of various ketone substrates (38 examples), achieving exceptional enantioselectivities of up to 99%. Through combined experimental investigations and density functional theory calculations, we proposed a plausible mechanistic pathway for the manganese-catalyzed ATH.
Authors
- Lin Zhang (ORCID: https://orcid.org/0000-0002-2608-8587)
- Chun Li (ORCID: https://orcid.org/0000-0002-4890-109X)
- Yu Tian
- Xuan Zhou (ORCID: https://orcid.org/0000-0001-8356-7747)
- Yue Zhou (ORCID: https://orcid.org/0000-0002-7797-4001)
- Pinli Dai
- Yingjian Xu
- Weimin Tian
- Yunhuan Wang
Institutions
- Guiyang Medical University (CN)
- Native American Technologies (United States) (US)
- Institute of New Materials (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1021/acs.joc.5c01944
- Citations
- 1
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.54