Urinary Branched-Chain Amino Acid Excretion and Chronic Kidney Disease Progression in Patients With Type 2 Diabetes
Restoration of branched-chain amino acid (BCAA) catabolism improves kidney pathology in animal models, but clinical data on the relationship between urinary BCAA excretion and kidney outcomes are scarce. Are urinary BCAA levels associated with CKD progression independent of clinical risk factors in patients with type 2 diabetes? High levels of urinary BCAAs predicted an increased risk of renal events independent of cardiorenal risk factors, with urinary MCP-1 mediating over 50% of the association. Activating intrarenal BCAA catabolism may potentially improve kidney function in patients with diabetes.
Authors
- Ming Shen Tham (ORCID: https://orcid.org/0000-0003-1726-0899)
- Huili Zheng (ORCID: https://orcid.org/0000-0002-3976-0088)
- Keven Ang (ORCID: https://orcid.org/0000-0002-7656-2523)
- Lye Siang Lee
- Jian-Jun Liu (ORCID: https://orcid.org/0000-0002-3361-7512)
- Janus Lee
- Subrata Debnath (ORCID: https://orcid.org/0000-0003-4245-8450)
- Thomas M. Coffman (ORCID: https://orcid.org/0000-0002-8433-1629)
- Resham L Gurung (ORCID: https://orcid.org/0000-0002-8772-4452)
- Jianhong Ching (ORCID: https://orcid.org/0000-0003-1526-8459)
- Chrong‐Reen Wang (ORCID: https://orcid.org/0000-0001-9881-7024)
- Su Chi Lim (ORCID: https://orcid.org/0000-0003-1742-5817)
- Kumar Sharma
- Sylvia Liu (ORCID: https://orcid.org/0000-0001-8561-7787)
Institutions
- National University of Singapore (SG)
- The University of Texas at San Antonio Health Science Center (US)
- Nanyang Technological University (SG)
- Khoo Teck Puat Hospital (SG)
- Precision for Medicine (United States) (US)
- National University Health System (SG)
- The University of Texas at San Antonio (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-11-21
- DOI
- https://doi.org/10.2337/db25-0782
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00